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Search Results for " bone resorption "

58

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21616	L-006235 L 006235	Cysteine Protease	Proteases/Proteasome
	L-006235 是一种口服有活性的、可逆的cathepsin K 选择性抑制剂，在骨吸收试验中的IC50值为 5 nM。它能够抑制胶原蛋白降解，并较少骨质流失。
T13324	VUF11207 fumarate	CXCR; Arrestin	Autophagy; GPCR/G Protein; Immunology/Inflammation
	VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体，pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化，pEC50分别为 8.8 和 7.9。
T6451	Clodronic acid disodium salt Loron,Clodronate Disodium,氯屈膦酸二钠,Lodronate	Others	Others
	Clodronic acid disodium salt (Lodronate) 是一种口服具有活力的破骨细胞骨吸收 (osteoclastic bone resorption) 的抑制剂，是一代双磷酸盐。它可用于高骨转换状态、Paget’s 病和溶骨性骨转移中。
T7566	GRGDSPK EMD 56574	Others	Others
	GRGDSPK (EMD 56574) 是一种包含精氨酸-甘氨酸-天冬氨酸 (RGD) 的多肽，也是一种竞争性且可逆的抑制肽，可抑制整联蛋白-纤连蛋白结合，可用于整联蛋白在骨形成和吸收中作用的研究。
T0308	Etidronic acid HEDPA,Etidronate,HEDP,羟乙磷酸	Apoptosis; Phosphatase; Others; HBV	Apoptosis; Metabolism; Microbiology/Virology; Others
	Etidronic acid (HEDP) 是一种影响钙代谢的二膦酸盐，抑制异位钙化并减缓骨吸收和骨转换，可应用于洗涤，水处理，化妆品和制药业。
T7566L1	GRGDSPK acetate GRGDSPK acetate(111119-28-9 Free base)	Beta Amyloid	Neuroscience
	GRGDSPK acetate 显示出对整合素-纤连蛋白结合的抑制活性，可用于研究整合素在骨形成和吸收中的作用。
T0309	Ipriflavone Osteofix,依普黄酮	advanced glycation end products	Others
	Ipriflavone (Osteofix) 是一种合成异黄酮衍生物，可用于抑制骨吸收。
T0379	Risedronic Acid Risedronate,利塞膦酸	Others; Transferase	Metabolism; Others
	Risedronic Acid (Risedronate) 具有抑制破骨细胞介导的骨重吸收的作用。
T21299	Zoledronic acid monohydrate 唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate	Apoptosis; Others; Autophagy	Apoptosis; Autophagy; Others
	Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐，具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡，有抗癌作用。
T0575	1-Methylimidazole	Others	Others
	1-Methylimidazole 是1-methyl-2-thioimidazole (methimazole)的代谢物，可抑制骨吸收。
T8489	Minodronic acid monohydrate	Transferase	Metabolism
	Minodronic acid monohydrate 是一种法尼基二磷酸合成酶抑制剂，可作为骨吸收抑制剂。
T6373	Alendronate sodium hydrate G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax	Transferase	Metabolism
	Alendronate sodium hydrate (MK 217) 是 farnesyl diphosphate synthase 抑制剂(IC50:460 nM)。
T1041	Risedronate Sodium NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠	HBV; Transferase	Metabolism; Microbiology/Virology
	Risedronate Sodium (NE 58095 Sodium) 是一种双磷酸盐，对破骨细胞介导的骨吸收具有抑制作用。
T2188	Thonzonium Bromide 嘧苯十六铵,通佐溴胺	Proton pump; Antibacterial; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Thonzonium bromide 是一种单阳离子表面活性剂，在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。
T1641	Strontium ranelate Distrontium renelate,S12911,雷尼酸锶	Calcium Channel; CaSR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Strontium ranelate (S12911) 是抗骨质疏松的药物，能够抑制骨吸收，促进骨形成，进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR)，进而促进肌醇 1，4，5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。
T3280	Clodronate disodium tetrahydrate clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的，可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐，具有抗骨质疏松、抗炎作用，可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP，缓解慢性神经病理性疼痛和炎症性疼痛。
TP1906L1	DPC AJ1951 acetate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	DPC-AJ1951 acetate 是一种 14 个氨基酸的肽，可作为甲状旁腺激素 (PTH)/PTH 相关肽受体 (PPR) 的有效激动剂。在骨吸收的体外和体内测定中表征了它的活性。
T1210	Sodium etidronate 依替膦酸钠,Didronel	Phosphatase	Metabolism
	Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员，etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量，从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。
T0291	Flurbiprofen 氟比洛芬,dl-Flurbiprofen	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Flurbiprofen (dl-Flurbiprofen) 是一种高效的，具有口服活性的非甾体抗炎化合物，有退热止痛活性, 常用于炎症性疾病的研究。它是一种非选择性的环氧合酶抑制剂，可研究结肠癌。
T20338	Methopterin NSC 107144,alpha-Methopterin,NSC-107144,10-Methylfolic acid,NSC107144
	Methopterin shows the activation and bone resorption function of murine osteoclasts.
T31902	Galactosylhydroxylysine Hydroxylysine-galactose
	Galactosylhydroxylysine residues present in bone type I collagen are terminal degradation products of the bone matrix that are released during bone resorption and excreted in the urine.
T27366	FR 78844 FR78844,FR-78844
	FR 78844 is an antagonist of bone resorption.
T29109	VPC12249 VPC-12249,VPC 12249
	VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity.
T70305	Zoledronate trisodium hydrate
	Zoledronate trisodium is a Bone Resorption Inhibitor and Osteoporosis Therapy Adjunct
T31940	Glucosylgalactosylhydroxylysine Hydroxylysine-glucose-galactose
	Glucosylgalactosylhydroxylysine is a bone formation and bone resorption marker that is related to bone turnover processes during growth and development as well as metabolic bone diseases.
T26512	ABD-295
	ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in vivo.
T36065	N-Oleoyl-L-Serine
	Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the maintenance of normal bone mass via signaling through the CB2 receptor. N-Oleoyl-L-serine is an endogenous lipid that has been reported to stimulate bone formation and to inhibit bone resorption.
T30836	Cgp 47072 Cgp-47072,Cgp47072
	Cgp 47072 is a bisphosphonate, used in the treatment of bone diseases, particularly where there is uncontrolled bone resorption.
T69996	A-75943
	A-75943 is a bone resorption inhibitor from streptomyces.
T27602	Incadronate Disodium YM-175,Cimadronate,YM175,YM 175
	Incadronate Disodium is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro.
TP2055	Calcitonin (human)
	Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.
T15206	Eldecalcitol 艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	Others	Others
	Eldecalcitol possesses a potent inhibitory effect on bone resorption and induces a significant increase in bone mineral density. Eldecalcitol is an orally active analogue of active vitamin D. It also is used in the treatment of osteoporosis .
T16092	L-873724	Others	Others
	L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of
TP1779	C-telopeptide
	C-telopeptide, a cross-linked peptide derived from type I collagen, is liberated through bone resorption and has demonstrated a correlation with bone mineral density (BMD).
T40463	Relacatib SB-462795
	Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in ...
T69443	Aminobutane bisphosphonate
	Aminobutane bisphosphonate is a powerful inhibitor of bone resorption. It can potentially be a useful measure for controlling hypercalcemia in patients with carcinoma.
TP1779L	C-telopeptide acetate C-telopeptide acetate(162929-64-8 free base)	Others	Others
	C-telopeptide acetate 是 I 型胶原蛋白的交联肽，可用作骨吸收的标志物。
T10187	6-Raloxifene-β-D-glucopyranoside	Others	Others
	6-Raloxifene-β-D-glucopyranoside is a benzothiophene glucuronidated at the 6' position. It is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss, resorption, and lowering lipid
T74736	2MD
	2MD是一种口服活性维生素D类似物，能刺激骨膜骨形成并减少小梁骨吸收，从而恢复小梁和皮质骨的质量与强度。在非人灵长类动物研究中，2MD还可以调节(IOP)相关基因，降低眼压。
T69082	Flurbiprofen sodium
	Flurbiprofen sodium is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting carbonic anhydrase.
T71150	Incadronic acid
	Incadronate, also known as Cimadronate and YM-175, is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro. Incadronate disodium is a bone density conservation, antitumor and anti-inflammatory agent.
T78278	Blosozumab
	Blosozumab (LY2541546)为针对人sclerostin (SOST)的单克隆抗体。它能促进骨生成，同时抑制骨吸收，可应用于骨质疏松症相关研究。
T73770	Galactosylhydroxylysine hydrochloride
	Galactosylhydroxylysine hydrochloride, 一种羟基赖氨酸经糖基化转换后生成的骨胶原蛋白成分，该化合物在骨吸收过程中释放，其浓度在代谢性骨丢失疾病中会上升。
T35826	PKC fragment (530-558)
	PKC fragment (530-558) 是蛋白激酶C (PKC) 的肽片段，是一种有效的 PKC 激活剂。Protein Kinase C (530-558) 可显著抑制破骨细胞骨吸收。
T37413	Calcitonin (salmon) (trifluoroacetate salt)
	Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and ...
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
T37409	DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 (trifluoroacetate salt)
	DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants...
T81591	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) Human PTHrP(107-111) amide
	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) 是一段具有抑制骨吸收作用的C端甲状旁腺激素相关蛋白片段。
T76657	Human PTH-(1-31)
	Human PTH-(1-31) 是人PTH的第1至31个氨基酸片段。它能够促进cAMP的释放，并作为25-羟基维生素D-1α-羟化酶的弱激活剂。此外，Human PTH-(1-31) 能够促进骨生成，而不引起骨质吸收，表明其在骨质疏松症研究中的应用潜力。
T36144	11β-Prostaglandin E2 11β-PGE2,11β-Prostaglandin E2
	11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3] .

化合物

Cat.No: T21616

Synonym: L 006235

Target: Cysteine Protease

VUF11207 fumarate

Cat.No: T13324

Target: CXCR, Arrestin

Clodronic acid disodium salt

Cat.No: T6451

Synonym: Loron,Clodronate Disodium,氯屈膦酸二钠,Lodronate

Target: Others

Cat.No: T7566

Synonym: EMD 56574

Target: Others

Cat.No: T0308

Synonym: HEDPA,Etidronate,HEDP,羟乙磷酸

Target: Apoptosis, Phosphatase, Others, HBV

GRGDSPK acetate

Cat.No: T7566L1

Synonym: GRGDSPK acetate(111119-28-9 Free base)

Target: Beta Amyloid

Cat.No: T0309

Synonym: Osteofix,依普黄酮

Target: advanced glycation end products

Risedronic Acid

Cat.No: T0379

Synonym: Risedronate,利塞膦酸

Target: Others, Transferase

Zoledronic acid monohydrate

Cat.No: T21299

Synonym: 唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate

Target: Apoptosis, Others, Autophagy

1-Methylimidazole

Cat.No: T0575

Target: Others

Minodronic acid monohydrate

Cat.No: T8489

Target: Transferase

Alendronate sodium hydrate

Cat.No: T6373

Synonym: G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax

Target: Transferase

Risedronate Sodium

Cat.No: T1041

Synonym: NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠

Target: HBV, Transferase

Thonzonium Bromide

Cat.No: T2188

Synonym: 嘧苯十六铵,通佐溴胺

Target: Proton pump, Antibacterial, Autophagy

Strontium ranelate

Cat.No: T1641

Synonym: Distrontium renelate,S12911,雷尼酸锶

Target: Calcium Channel, CaSR

Clodronate disodium tetrahydrate

Cat.No: T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

Target: IL Receptor, TNF

DPC AJ1951 acetate

Cat.No: TP1906L1

Target: Thyroid hormone receptor(THR)

Sodium etidronate

Cat.No: T1210

Synonym: 依替膦酸钠,Didronel

Target: Phosphatase

Cat.No: T0291

Synonym: 氟比洛芬,dl-Flurbiprofen

Target: Apoptosis, COX, MRP

Cat.No: T20338

Synonym: NSC 107144,alpha-Methopterin,NSC-107144,10-Methylfolic acid,NSC107144

Galactosylhydroxylysine

Cat.No: T31902

Synonym: Hydroxylysine-galactose

Cat.No: T27366

Synonym: FR78844,FR-78844

Cat.No: T29109

Synonym: VPC-12249,VPC 12249

Zoledronate trisodium hydrate

Cat.No: T70305

Glucosylgalactosylhydroxylysine

Cat.No: T31940

Synonym: Hydroxylysine-glucose-galactose

Cat.No: T26512

N-Oleoyl-L-Serine

Cat.No: T36065

Cat.No: T30836

Synonym: Cgp-47072,Cgp47072

Cat.No: T69996

Incadronate Disodium

Cat.No: T27602

Synonym: YM-175,Cimadronate,YM175,YM 175

Calcitonin (human)

Cat.No: TP2055

Cat.No: T15206

Synonym: 艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Target: Others

Cat.No: T16092

Target: Others

Cat.No: TP1779

Cat.No: T40463

Synonym: SB-462795

Aminobutane bisphosphonate

Cat.No: T69443

C-telopeptide acetate

Cat.No: TP1779L

Synonym: C-telopeptide acetate(162929-64-8 free base)

Target: Others

6-Raloxifene-β-D-glucopyranoside

Cat.No: T10187

Target: Others

Cat.No: T74736

Flurbiprofen sodium

Cat.No: T69082

Incadronic acid

Cat.No: T71150

Cat.No: T78278

Galactosylhydroxylysine hydrochloride

Cat.No: T73770

PKC fragment (530-558)

Cat.No: T35826

Calcitonin (salmon) (trifluoroacetate salt)

Cat.No: T37413

TNF-α Antagonist

Cat.No: T36127

DPC-AJ1951 (trifluoroacetate salt)

Cat.No: T37409

Synonym: DPC-AJ1951 (trifluoroacetate salt)

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)

Cat.No: T81591

Synonym: Human PTHrP(107-111) amide

Human PTH-(1-31)

Cat.No: T76657

11β-Prostaglandin E2

Cat.No: T36144

Synonym: 11β-PGE2,11β-Prostaglandin E2

Cat. No.	Product Name	Target	Signaling Pathways
TN1494	Cimicifugoside H-1 黑升麻苷H-1	Others	Others
	Cimicifugoside H1 是C. foetidaL.C 提取物的主要成分，是一种环甾烷醇木糖苷。它对骨吸收及卵巢切除术引起的骨质流失具有抑制作用。
T2988	(-)-Epigallocatechin Gallate Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG	Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	(-)-Epigallocatechin Gallate (EGCG) 是茶类黄酮，具有强大的抗氧化，抗炎和抗癌作用。它可抑制EGFR 信号传导，有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。
TN1117	Veraguensin	p38 MAPK; NF-κB; Antibiotic; Parasite; Antifection	MAPK; Microbiology/Virology; NF-κB
	Veraguensin 来源于 Magnolia sp.。 Veraguensin 抑制骨吸收并显示出高抗寄生虫活性。
T3488	Tectorigenin 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素	Apoptosis	Apoptosis
	Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) 是一种从葛根汤干燥的花中分离出来的植物异黄酮。
T3808	Icariside I 淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I	Others	Others
	Icariside I (Lcariside I) 是一种 Icarlin 的代谢产物，具有调节骨重塑的作用，可用于研究骨质疏松。
TN2143	3,7,4'-Trihydroxyflavone Resokaempferol,5-Deoxykampferol	DNA	DNA Damage/DNA Repair
	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物，可抑制 NF-κB 配体（RANKL）受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。
T6316	Calcitriol Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3	Endogenous Metabolite	Metabolism
	Calcitriol (1,25-Dihydroxyvitamin D3) 是一种维他命 D 的代谢物，一种维他命 D 受体 (VDR) 的激动剂 (IC50=0.4 nM)。Calcitriol 增加肠道对钙和磷的吸收，并与甲状旁腺激素一起增加了骨吸收。
T3804	Neomangiferin Mangiferin 7-glucoside,新芒果苷	Phosphatase	Metabolism
	Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone，分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。
T3S2312	Poncirin 枸橘苷,Isosakuranetin-7-neohesperidoside	Apoptosis; Others	Apoptosis; Others
	Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物，具有抗炎活性。它防止脂肪生成，增强间充质干细胞中的成骨细胞分化，增加骨矿物质密度，改善小梁微结构，可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
T3S0137	Bavachalcone	Antibacterial; Antibiotic	Microbiology/Virology
	Bavachalcone 是从补骨脂中分离的化合物，广泛用于中药，具有抗生素和抗癌等活性。
TN1711	Gossypetin	Antioxidant; p38 MAPK; MAPK; Antibacterial	MAPK; Microbiology/Virology; oxidation-reduction
	Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮，是一种有效的 MKK3 和 MKK6 抑制剂，可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用，它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。
T4237	Rubiadin-1-methyl ether Rubiadin 1-methyl ether,3-羟基-1-甲氧基-2-甲基蒽醌	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) 是一种巴戟天中的蒽醌类化合物，能够抑制 NF-κB p65 的磷酸化和 IκBα 的降解以及减少 p65 的核转位，阻碍破骨细胞的骨吸收。
TN1215	(2S)-2'-Methoxykurarinone 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt; Antifection	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物，具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号，抑制破骨细胞形成和骨吸收。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
T38799	2,3-Bis(3-indolylmethyl)indole
	2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.
T31382	Deoxypyridinoline Lysylpyridinoline
	Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity.
TN1536	Curculigoside B	Others	Others
	Curculigoside B shows antioxidative and antiosteoporotic activities, it can decrease area of bone resorption pit, osteoclastic formation and TRAP activity.
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste...
T72916	Justicidin B 爵床脂素B
	Justicidin B是一种高效的抗癌木脂素及促凋亡剂，同时具备显著的骨吸收抑制作用，并展现出强大的抗病毒、杀真菌和抗原虫能力。此外，Justicidin B能显着抑制血小板聚集。
TN2775	2-Methoxystypandrone	MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant

天然产物

Cimicifugoside H-1

Cat.No: TN1494

Synonym: 黑升麻苷H-1

Target: Others

(-)-Epigallocatechin Gallate

Cat.No: T2988

Synonym: Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

Cat.No: TN1117

Target: p38 MAPK, NF-κB, Antibiotic, Parasite, Antifection

Cat.No: T3488

Synonym: 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素

Target: Apoptosis

Cat.No: T3808

Synonym: 淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I

Target: Others

3,7,4'-Trihydroxyflavone

Cat.No: TN2143

Synonym: Resokaempferol,5-Deoxykampferol

Target: DNA

Cat.No: T6316

Synonym: Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3

Target: Endogenous Metabolite

Cat.No: T3804

Synonym: Mangiferin 7-glucoside,新芒果苷

Target: Phosphatase

Cat.No: T3S2312

Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

Cat.No: T3S0137

Target: Antibacterial, Antibiotic

Cat.No: TN1711

Target: Antioxidant, p38 MAPK, MAPK, Antibacterial

Rubiadin-1-methyl ether

Cat.No: T4237

Synonym: Rubiadin 1-methyl ether,3-羟基-1-甲氧基-2-甲基蒽醌

Target: Anti-infection, NF-κB

(2S)-2'-Methoxykurarinone

Cat.No: TN1215

Synonym: 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

2,3-Bis(3-indolylmethyl)indole

Cat.No: T38799

Deoxypyridinoline

Cat.No: T31382

Synonym: Lysylpyridinoline

Curculigoside B

Cat.No: TN1536

Target: Others

Cat.No: T36295

Cat.No: T37008

Cat.No: T72916

Synonym: 爵床脂素B

2-Methoxystypandrone

Cat.No: TN2775

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

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